Substituted macrocyclic indole derivatives
The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinat...
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| creator | Johannes, Sarah Anna Liesa Fitzgerald, Mark Mengel, Anne Furst, Laura Werbeck, Nicolas Wei, Guo McCarren, Patrick Ryan Wittrock, Sven Serrano-Wu, Michael H Buchgraber, Philipp Klar, Ulrich Thede, Kai Lazarski, Kiel Kaulfuss, Stefan Fernandez-Montalvan, Amaury Ernesto McKinney, David Nowak-Reppel, Katrin Christ, Clara Rauh, Ulrike Moenning, Ursula Kuhnke, Joachim Lemke, Chris Nasveschuk, Christopher Ferrara, Steven James Harvey, Rebecca Ann |
| description | The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Substituted macrocyclic indole derivatives |
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