Substituted macrocyclic indole derivatives

The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinat...

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Hauptverfasser:	Johannes, Sarah Anna Liesa, Fitzgerald, Mark, Mengel, Anne, Furst, Laura, Werbeck, Nicolas, Wei, Guo, McCarren, Patrick Ryan, Wittrock, Sven, Serrano-Wu, Michael H, Buchgraber, Philipp, Klar, Ulrich, Thede, Kai, Lazarski, Kiel, Kaulfuss, Stefan, Fernandez-Montalvan, Amaury Ernesto, McKinney, David, Nowak-Reppel, Katrin, Christ, Clara, Rauh, Ulrike, Moenning, Ursula, Kuhnke, Joachim, Lemke, Chris, Nasveschuk, Christopher, Ferrara, Steven James, Harvey, Rebecca Ann
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.