Functionalized n-acetylgalactosamine analogs

Functionalized n-acetylgalactosamine analogs

Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functional...

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Bibliographische Detailangaben
Hauptverfasser: Zou, Mufa, Guan, Xiaoyang, Lau, Aldrich N. K, Zhao, Gang, Poon, Wing C, Yu, David, Yao, Yun-Chiao, Du, Gengyu, Zheng, Xiaoling, Zou, Ruiming
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.