Detecting and treating COPD-OSA overlap syndrome

The present ventilator system, for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA event(s)) overlap syndrome, comprises a pressure generator for generating a pressurized flow of breathable gas for delivery to an airway of a subject; sensor(s) for generating output signals conveying information related to breathable gas parameters; and processor(s) operatively connected to the sensor(s) and the pressure generator, configured to: detect presence of OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals. Responsive to detecting concurrent presence of OSA event(s) and EFL, the processors are configured to determine OSA EVENT(S) therapy parameters for treating the detected OSA event(s) in the subject; determine EFL therapy parameters for treating the detected EFL in the subject; determine a priority treatment based on a comparison between the OSA event(s) therapy parameters and the EFL therapy parameters; and control the pressure generator.