Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof

Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof

A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tang, Cha-Mei, Li, Shuhong, Adams, Daniel, Amstutz, Platte T, Zhu, Peixuan, Makarova, Olga
Format: Patent
Sprache:eng
Schlagworte:
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
SEPARATION
TESTING
TRANSPORTING
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Beschreibung
Zusammenfassung:A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.