Ready to use injectable formulations of melphalan and processes for preparation thereof

The present application provides stable ready-to-use injectable formulations of melphalan, methods for preparing storage-stable, ready-to-use injectable formulations that include melphalan, which are easy to administer without need of any reconstitution step and has a desirable solubility, stability...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kasu, Raghu, Kannappan, Jayaraman, Kovi, Ravishanker, Reddy, Thupalli Ajeykumar, Yekkanti, Vamshi
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present application provides stable ready-to-use injectable formulations of melphalan, methods for preparing storage-stable, ready-to-use injectable formulations that include melphalan, which are easy to administer without need of any reconstitution step and has a desirable solubility, stability, and safety profile. In other embodiments, provided are storage-stable, ready-to-use, injectable liquid parenteral formulations that include melphalan and other pharmaceutically acceptable excipients.