Bispecific antibodies with specific binding to CD47 and PD-L1

Bispecific antibodies with specific binding to CD47 and PD-L1

The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ulitin, Andrei Borisovich, Nemankin, Timofey Aleksandrovich, Solovyev, Valery Vladimirovich, Solovyev, Kirill Vladimirovich, Morozov, Dmitry Valentinovich
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.