Electrical isolation of neurostimulation circuitry from neurorecording circuitry

Various embodiments of an interface control subsystem may be used between an electrode terminal and a recording terminal of a neurostimulation and neurorecording system. The interface control subsystem may operate in three modes. In a disable mode, a first transistor and a second transistor disposed between the electrode terminal and the recording terminal may operate in a cutoff region and generate a high impedance. In an active mode, the first transistor and the second transistor may operate in a saturation region and generate a low impedance. In a stimulation mode, the first transistor and the second transistor operate in a triode region and generate an impedance between the high impedance of the disable mode and the low impedance of the active mode. The interface control subsystem may further limit voltage at the recording terminal in response to a detected overvoltage condition.