Immunoproteasome inhibitors

Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brameld, Kenneth Albert, Owens, Timothy Duncan, Lou, Yan, Goldstein, David Michael
Format: Patent
Sprache:eng
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Zusammenfassung:Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.