Pyrazolopyridine derivatives and uses thereof

Pyrazolopyridine derivatives and uses thereof

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hesse, Matthew James, Thomsen, Noel Marie-France, Manning, James R, Cernijenko, Artiom, Kerrigan, John Ryan, Cobb, Jennifer Stroka, Dewhurst, Janetta, Jain, Rama, Bonazzi, Simone, Dales, Natalie Alysia, Patterson, Andrew W, O'Brien, Gary, Malik, Hasnain Ahmed, Ting, Pamela Y F
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.