Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- an...

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Hauptverfasser:	Su, Yongli, Yan, Xuelei, Mailyan, Artur Karenovich, Rosen, Brandon Reid, Drew, Samuel Lawrie, Haelsig, Karl T, Lindsey, Erick Allen, Powers, Jay Patrick, Wang, Zhang, Fournier, Jeremy Thomas Andre, Leleti, Manmohan Reddy, Jeffrey, Jenna Leigh, Beatty, Joel Worley, Gal, Balint, Yu, Kai, Mata, Guillaume, Epplin, Matthew, Kalisiak, Jaroslaw, Hardman, Clayton, Lawson, Kenneth Victor, Mandal, Debashis, Guney, Tezcan, Tran, Anh Thu, Jacob, Steven Donald, Moon, Hyunyoung
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.