Spirocyclic compounds as tryptophan hydroxylase inhibitors

The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pul...

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Bibliographische Detailangaben
Hauptverfasser: De Lombaert, Stéphane, Scribner, Andrew, Brameld, Kenneth, Sjogren, Eric Brian, Goldberg, Daniel R
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.