Method of operating a flexographic printing press, and system

A method of operating a flexographic printing press having a printing cylinder carrying a sleeve with at least one flexographic printing forme or a flexographic printing cylinder, and an impression cylinder, includes adjusting contact pressure between the printing cylinder or the flexographic printing cylinder and the impression cylinder by motor. The adjustment is made in an automated way as a function of a dot density of the flexographic printing forme, i.e. of a location-dependent density of printing elevations on the flexographic printing forme or data computationally derived therefrom. A cost-efficient way of producing high-quality prints in an industrial flexographic printing process is thus provided. In addition, the method advantageously provides further automation of the printing process. A flexographic printing press, a flexographic printing press system, and a flexographic printing forme or sleeve for a flexographic printing forme are also provided.