Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having th...

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Bibliographische Detailangaben
Hauptverfasser: Talbot, Adam Charles, Campbell, Ann-Marie, Buckmelter, Alexandre Joseph, Wang, Minghua, Lancia, Jr., David R, Follows, Bruce, Ioannidis, Stephanos
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.