Read sample offset bit determination in a memory sub-system

The present disclosure is directed to read sample offset most probable bit operation associated with a memory component. A processing device generates a first set of read data associated with a memory component, the first set of read data comprising a first sequence of bit values. The processing device generates a second set of read data associated with the memory component, the second set of read data comprising a second sequence of bit values. The processing device generates a third set of read data associated with the memory component, the third set of read data comprising a third sequence of bit values. A most probable bit operation is performed to compare the first sequence of bit values, the second sequence of bit values, and the third sequence of bit values to generate and store a most probable bit sequence.