Zinc sensors for in vivo imaging of beta-cell function by MRI

In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.

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Bibliographische Detailangaben
Hauptverfasser:	Jordan, Maria Veronica Clavijo, Chirayil, Sara, Sherry, A. Dean, Martins, Andre F
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DIAGNOSIS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE IDENTIFICATION MEASURING MEASURING ELECTRIC VARIABLES MEASURING MAGNETIC VARIABLES MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SURGERY TESTING
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Beschreibung
Zusammenfassung:	In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.