Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates

The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody dru...

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Bibliographische Detailangaben
Hauptverfasser:	Filzen, Gary Frederick, Che, Ye, Young, Jennifer, Dushin, Russell George, Starr, Jeremy, Abramite, Joseph A, Gilbert, Adam Matthew, O'Donnell, Christopher John, Uccello, Daniel P, Casavant, Jeffrey M, Moine, Ludivine, Flanagan, Mark, Tumey, Lawrence N, Roberts, Lee R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.