Human plasma kallikrein inhibitors

Disclosed are compounds of formula I:as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions...

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Bibliographische Detailangaben
Hauptverfasser: Kumar, V. Satish, Kotian, Pravin L, Chintareddy, Venkat R, Babu, Yarlagadda S, Zhang, Weihe, Wu, Minwan
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are compounds of formula I:as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.