Chemical compounds
The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to HbS modulators of formula (I)or tautomers thereof, or pharmaceutically a...
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| creator | Parikh, Mihir Dineshkumar Casimiro-Garcia, Agustin Chen, Ming Zhu Robinson, Jr., Ralph Pelton Cabral, Shawn Fadeyi, Olugbeminiyi Omezia Yayla, Hatice Gizem Dow, Robert Lee Jones, Lyn Howard Narayanan, Arjun Venkat Roberts, Lee Richard Jasti, Jayasankar Hepworth, David Gopalsamy, Ariamala Choi, Chulho Piotrowski, David Walter |
| description | The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to HbS modulators of formula (I)or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD). |
| format | Patent |
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Casimiro-Garcia, Agustin ; Chen, Ming Zhu ; Robinson, Jr., Ralph Pelton ; Cabral, Shawn ; Fadeyi, Olugbeminiyi Omezia ; Yayla, Hatice Gizem ; Dow, Robert Lee ; Jones, Lyn Howard ; Narayanan, Arjun Venkat ; Roberts, Lee Richard ; Jasti, Jayasankar ; Hepworth, David ; Gopalsamy, Ariamala ; Choi, Chulho ; Piotrowski, David Walter</creatorcontrib><description>The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to HbS modulators of formula (I)or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Chemical compounds |
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