Chemical compounds

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to HbS modulators of formula (I)or tautomers thereof, or pharmaceutically a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Parikh, Mihir Dineshkumar, Casimiro-Garcia, Agustin, Chen, Ming Zhu, Robinson, Jr., Ralph Pelton, Cabral, Shawn, Fadeyi, Olugbeminiyi Omezia, Yayla, Hatice Gizem, Dow, Robert Lee, Jones, Lyn Howard, Narayanan, Arjun Venkat, Roberts, Lee Richard, Jasti, Jayasankar, Hepworth, David, Gopalsamy, Ariamala, Choi, Chulho, Piotrowski, David Walter
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to HbS modulators of formula (I)or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).