Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy

A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for...

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Bibliographische Detailangaben
Hauptverfasser: Vaughan, Hannah, Green, Jordan J, Gadens Zamboni, Camila, Pomper, Martin G, Minn, Il
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.