5-membered and bicyclic heterocyclic amides as inhibitors of ROCK

The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising the...

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Bibliographische Detailangaben
Hauptverfasser:	Thiyagarajan, Kamalraj, Glunz, Peter W, Ladziata, Vladimir, Maishal, Tarun Kumar, De Lucca, Indawati, Tangirala, Raghuram, Tora, George O
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.