Antisense oligonucleotides and uses thereof

Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hernández Ribera, Jordi, Bechara, Elias, Serrano Marugán, Manuel, Fernández Marcos, Pablo José, Rovira Del Olmo, Miguel, Valcárcel Juárez, Juan Alberto
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.