Configuration cluster-based performance optimization of applications in an information handling system (IHS)

Embodiments of systems and methods for managing performance optimization of a target application executed by an Information Handling System (IHS) are described. In an illustrative, non-limiting embodiment, an IHS may includes executable code to measure a performance of a target application at each of multiple configuration clusters that are applied to an IHS in which each configuration cluster includes multiple configuration settings of one or more resources that are used to execute the target application on the IHS. Using the measured performance values, the instructions may then select one of the configuration clusters that causes the target application to operate at an optimum performance level, and modify the IHS to operate with the one selected configuration cluster.