Compounds for the treatment of BRAF-associated diseases and disorders

Compounds for the treatment of BRAF-associated diseases and disorders

Provided herein are compounds of the Formula I:and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant an...

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Bibliographische Detailangaben
Hauptverfasser: Cook, Adam Wade, Kahn, Dean Russell, Hicken, Erik James, Pajk, Spencer Phillip, Laird, Ellen Ruth, Moreno, David Austin, Brown, Katie Keaton, Newhouse, Bradley Jon, Metcalf, Andrew Terrance, Tarlton, Eugene, Prigaro, Brett Joseph, Ren, Li, Barbour, Patrick Michael
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Provided herein are compounds of the Formula I:and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.