Intra-surgery imaging system

Various embodiments discussed herein utilize a C-shaped imager to provide images with a minimal footprint, such as may be suitable in a surgical context. In addition the systems and methods described herein allow for suitable angular (i.e., azimuthal) scan coverage about the patient. To provide real-time 3D imaging, multiple X-ray tubes or a distributed X-ray source may be employed, coupled with an extended detector or multiple detectors. To reconstruct high-quality volumes, in some implementations reconstruction techniques may be employed that utilize pre-operative (pre-op) computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (U/S), or other suitable modality images or data as prior information.