Footwear with flexible cage and wedge

An article of footwear includes an upper, a midsole, and an outsole, where the midsole is located between the outsole and the upper. A wedge is located between the outsole and the midsole and is preferably made of a material that is less compressible than the midsole. A flexible cage is located on the exterior surfaces of the upper and midsole. In embodiments, the flexible cage is designed to limit the outward expansion of the midsole when the midsole is compressed under load, and thus effectively stiffen the midsole. The total compression of the midsole of the article of footwear is based, at least in part, on a desired orientation of the ankle, knee, and hip joints of a user.