Carboxy substituted glucocorticoid receptor agonists

Carboxy substituted glucocorticoid receptor agonists

The present invention provides a compound of Formula I:wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy;R2 is H or halogen; andX is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wurst, Jacqueline Mary, Stites, Ryan Edward
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:The present invention provides a compound of Formula I:wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy;R2 is H or halogen; andX is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis, and lupus nephritis.