Compounds useful for inhibiting RET kinase

Compounds useful for inhibiting RET kinase

Provided herein are RET kinase inhibitors according to the formula:pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Anderson, Erin D, Munchhof, Michael J, Welch, Michael B, Andrews, Steven W, McKenney, Megan, Irvin, Thomas C, Kumar, Manoj, McFaddin, Elizabeth A, Condroski, Kevin R, Kolakowski, Gabrielle R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided herein are RET kinase inhibitors according to the formula:pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.