Inhibition of dipeptide repeat proteins

Methods are disclosed for treating neurodegenerative disorders, such as ALS and FTD by using an effective amount of a type I protein arginine methyltransferase (Type I PRMT) inhibitor to decrease cellular toxicity caused by dipeptide repeat proteins (DRPs).

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Bibliographische Detailangaben
Hauptverfasser: Vieira, Fernando G, Gill, Anna, Premasiri, Alan
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Methods are disclosed for treating neurodegenerative disorders, such as ALS and FTD by using an effective amount of a type I protein arginine methyltransferase (Type I PRMT) inhibitor to decrease cellular toxicity caused by dipeptide repeat proteins (DRPs).