Antibodies binding to VISTA at acidic pH

Antibodies binding to VISTA at acidic pH

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significa...

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Bibliographische Detailangaben
Hauptverfasser: Rakestraw, Ginger, Borges, Luis, Rajpal, Arvind, Su, Lin Hui, Sheppard, Paul O, Bahjat, Keith Sadoon, Deng, Andy X, Johnston, Robert J, Rankin, Andrew, Korman, Alan J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.