Cyclic dinucleotides as sting agonists

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.

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Bibliographische Detailangaben
Hauptverfasser:	Schepens, Wim Bert Griet, Viellevoye, Marcel, Richter, Mark, Connolly, Peter J, Edwards, James P, Wang, Guangyi, Thatikonda, Santhosh Kumar, Beigelman, Leonid, Bignan, Gilles, Thuring, Johannes Wilhelmus J. F, Emanuel, Stuart
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.