Sealing boots for protecting optical interconnections and related assemblies

The present disclosure describes sealing boots for protecting an optical interconnection. A sealing boot may include a main body having an interior cavity, the interior cavity having an annular recess adjacent to one end of the main body, the annular recess configured to receive a feature of a remote radio unit, and a neck merging with the opposing end of the main body and having a cylindrical inner surface that defines a bore that is continuous with the cavity of the main body, the inner surface having an inner diameter that is less than an inner diameter of the interior cavity of the main body. The sealing boot is configured to surround at least a portion of a fixed active optical connector when the fixed active optical connector is plugged into the remote radio unit.