Method for efficiently inducing antibody, antibody and detection system for hepatitis virus

An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan...

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Hauptverfasser: Chiba, Yasunori, Kuno, Atsushi, Togayachi, Akira, Mizokami, Masashi, Korenaga, Masaaki, Tajiri, Kazuto, Narimatsu, Hisashi, Sogabe, Maki, Kaji, Hiroyuki, Angata, Kiyohiko, Sato, Takashi, Ozawa, Tatsuhiko, Shimizu, Hiroki, Wagatsuma, Takanori
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Sprache:eng
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Zusammenfassung:An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.