Sulfonylurea compounds as inhibitors of interleukin-1 activity

Sulfonylurea compounds as inhibitors of interleukin-1 activity

The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

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Bibliographische Detailangaben
Hauptverfasser: Staben, Steven Thomas, Volgraf, Matthew, McBride, Christopher, Veal, James M, Pastor, Richard M, Trzoss, Lynnie Lin, Stivala, Craig, Stafford, Jeffrey A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.