Amino acid compounds and methods of use

Amino acid compounds and methods of use

The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for tre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jiang, Lan, Bailey, Christopher, Zheng, Yajun, Dong, Chengguo, Reilly, Maureen, Finklestein, Darren, Li, Hui, Leftheris, Katerina, Munoz, Manuel, Hom, Timothy, Morgans, Jr., David John, Cha, Jacob
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).