Control nucleic acids, and compositions, kits, and uses thereof

Provided are methods, as well as compositions, kits, and systems for preparing optimized control nucleic acids (polynucleotides) having reduce nucleic acid damage. Provided nucleic acid compositions provide reduced artifacts as compared to nucleic acid compositions prepared by conventional methods....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dhingra, Dalia, Chien, Richard
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided are methods, as well as compositions, kits, and systems for preparing optimized control nucleic acids (polynucleotides) having reduce nucleic acid damage. Provided nucleic acid compositions provide reduced artifacts as compared to nucleic acid compositions prepared by conventional methods. Provided compositions are useful control in a variety of applications, including, but not limited to sequencing workflows to effectively monitor sensitivity, accuracy and/or precision of data.