Engineered stable CH2 polypeptides

Engineered stable CH2 polypeptides

This invention relates to engineered CH2 domain molecules containing amino acids in the framework regions that confer enhanced stability and/or solubility. In particular, the invention provides engineered CH2 domain molecules containing amino acid residues that differ from a wild type CH2 domain or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Gehlsen, Kurt R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMBINATORIAL CHEMISTRY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:This invention relates to engineered CH2 domain molecules containing amino acids in the framework regions that confer enhanced stability and/or solubility. In particular, the invention provides engineered CH2 domain molecules containing amino acid residues that differ from a wild type CH2 domain or a template CH2 domain molecule within one or more framework regions and that result in improved stability and/or solubility.