Dosage forms of tafamidis and its pharmaceutically acceptable salt thereof

The disclosure relates to a novel dosage form comprising hard gelatin capsule having granule composition, spray dried or evaporated composition containing tafamidis or its pharmaceutically acceptable salt particularly tafamidis meglumine and tablet comprising tafamidis or its pharmaceutically accept...

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Bibliographische Detailangaben
Hauptverfasser: Balaiah, Erugu, Shanmugam, Muthusamy, Venkatragavan, Ramasamy, Sakthikumar, Thirunavukkarasu, Madhukar, Singavarapu Ajay, Sivakumar, Palanisamy
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The disclosure relates to a novel dosage form comprising hard gelatin capsule having granule composition, spray dried or evaporated composition containing tafamidis or its pharmaceutically acceptable salt particularly tafamidis meglumine and tablet comprising tafamidis or its pharmaceutically acceptable salt particularly tafamidis meglumine that would not form a rigid gel upon contacting with water or buffer solution in dissolution specifically pH 6.8 phosphate buffer and that composition is indicated for the treatment of the cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.