Dynamically enabling or disabling controls of a controller

A handheld controller may include controls that are actuatable by a user. The handheld controller may further include one or more sensors that are configured to detect an object in proximity to certain controls, and/or that sense a grip or position of a hand on a handle portion of the controller. Based on data from a sensor(s), certain controls may be enabled and/or disabled. The sensors may therefore be used to determine which controls are being used or are intended to be used, and/or which controls are likely accessible or inaccessible to the user based on sensor data, and to cause one or more controls of the handheld controller to be enabled and/or disabled accordingly.