Apparatus and method for transmitting and receiving asynchronous signal in wireless communication system

The present disclosure relates to a communication method and system for converging a 5th-generation (5G) communication system or a 6th-generation (6G) communication system for supporting higher data rates beyond a 4th-generation (4G) system. The disclosure relates to an operating method of a terminal in a wireless communication system. The method may include: receiving configuration information about a plurality of signatures for non-orthogonal multiple access (NOMA) from a base station, the plurality of signatures including first signatures and second signatures; identifying a first signature sequence for the terminal, based on the configuration information; and transmitting data, configured based on the identified first signature sequence, to the base station, wherein the first signature sequence may be configured by repeating the first signatures, and the first signatures may be respectively applied to consecutive symbols of the data.