Highly sensitive immunoassay with large particle labels

Highly sensitive immunoassay with large particle labels

An immunoassay for the detection of an analyte in a sample includes a plurality of moieties capable of binding to the analyte. Capture moieties, which are not specific for the same epitope, are bound to a solid substrate, and at least one epitope-specific detection moiety is bound to a detectable ma...

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Bibliographische Detailangaben
Hauptverfasser: Evers, Toon Hendrik, Dittmer, Wendy Uyen, Martens, Michael Franciscus Wilhelmus Cornelis, Hefti, Marco Hendrikus, Dekkers, David Walterus Cornelis
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:An immunoassay for the detection of an analyte in a sample includes a plurality of moieties capable of binding to the analyte. Capture moieties, which are not specific for the same epitope, are bound to a solid substrate, and at least one epitope-specific detection moiety is bound to a detectable marker. The detectable marker is a large particle marker having a particle size of ≥50 nm and ≤5000 nm.