Direct response to IO request in storage system with remote replication

An apparatus comprising a processing device is configured to communicate with a storage node of a storage system via at least one network and to communicate with a compute node that implements at least a portion of an application via the at least one network. The at least one processing device is configured to obtain an input-output request associated with the application from the compute node via the at least one network and to associate information corresponding to the compute node with the input-output request. The at least one processing device is further configured to submit the input-output request and the associated information that corresponds to the compute node to the storage node. The storage node is configured to submit a response to the input-output request to the compute node via the at least one network based at least in part on the information.