Inhibitors of the menin-MLL interaction

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

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Bibliographische Detailangaben
Hauptverfasser:	Claremon, David A, Zheng, Yajun, Marcus, Andrew, Yuan, Jing, Cacatian, Salvacion, Dillard, Lawrence Wayne, Singh, Suresh B, Morales-Ramos, Angel, Venkatraman, Shankar, Houston, Travis L, Parent, Stephan D, Dong, Chengguo, Lotesta, Stephen D, Zhuang, Linghang, Jia, Lanqi, Fan, Yi
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.