Realizing private and practical pharmacological collaboration using a neural network architecture configured for reduced computation overhead

Computationally-efficient techniques facilitate secure pharmacological collaboration with respect to private drug target interaction (DTI) data. In one embodiment, a method begins by receiving, via a secret sharing protocol, observed DTI data from individual participating entities. A secure computation then is executed against the secretly-shared data to generate a pooled DTI dataset. For increased computational efficiency, at least a part of the computation is executed over dimensionality-reduced data. The resulting pooled DTI dataset is then used to train a neural network model. The model is then used to provide one or more DTI predictions that are then returned to the participating entities (or other interested parties).