Flexible datapath offload chaining

Described are platforms, systems, and methods for processing a chain of operations through an input output (IO) subsystem without central processing unit (CPU) involvement. In one aspect, a computer-implemented method comprises: providing, via the CPU, the chain of operations to the IO subsystem, wherein the IO subsystem is coupled to the one or more processors over Peripheral Component Interconnect Express (PCIe); processing, with the IO subsystem, the chain of operations by: retrieving, from a memory, data associated with the chain of operations; executing each of the operations in the chain to determine an output based on the data and output determined for any prior executed operation in the chain; and providing the output of each the executed operations for execution of the respective next operation in the chain; and providing, via the IO subsystem, an output for the chain of operations to the CPU.