Tetrahydroisoquinoline derivative, preparation method therefor and use thereof

Tetrahydroisoquinoline derivative, preparation method therefor and use thereof

Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jiang, Guoping, Liao, Weiwei, Chen, Lei, Hu, Taishan, Meng, Lichen, Huang, Xiangui, Guo, Yanghui
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.