Systems and methods for power protection on failed memory devices

An information handling system may include a memory comprising a plurality of memory modules, each memory module comprising a plurality of memory chips, a host system comprising a host system processor configured to, during a boot of the information handling system, execute a basic input/output system of the information handling system configured to monitor for one or more faults of one or more memory modules of the plurality of memory modules, and control circuitry. The control circuitry may be configured to, in response to the one or more faults, determine if, all of one or more memory modules associated with a power control signal of such one or more memory modules have experienced faults, and if all of the one or more memory modules associated with the power control signal have experienced faults, de-assert the power control signal such that the one or more memory modules are de-energized.