Methods of preparing inhibitors of influenza viruses replication

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof:comprises: (a) reacting Compound (X):or a pharmaceutically acceptable salt thereof with Compound (Y):in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z):or a pharmaceutically a...

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Bibliographische Detailangaben
Hauptverfasser:	Dvornikovs, Vadims, Tanoury, Gerald J, Nugent, William Aloysius, Rose, Peter Jamison
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof:comprises: (a) reacting Compound (X):or a pharmaceutically acceptable salt thereof with Compound (Y):in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z):or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.