Method for preparing microcapsules and microparticles of controlled size

The present invention relates to a method for the preparation of microparticles and solid microcapsules comprising the following steps:a) the addition, with stirring, of composition C′2 in a composition C3, the compositions C′2 and C3 not being miscible with each other, the composition C′2 being eit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Demoulin, Damien, Walters, Jamie
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a method for the preparation of microparticles and solid microcapsules comprising the following steps:a) the addition, with stirring, of composition C′2 in a composition C3, the compositions C′2 and C3 not being miscible with each other, the composition C′2 being either a monophasic composition C2 or an emulsion (E1) comprising drops of a composition C1, comprising at least one active ingredient, dispersed in a polymeric composition C2, the compositions C1 and C2 not being miscible in each other, the viscosity of composition C3 being greater than 10,000 mPa·s at 25° C. at a shear rate of s−1 and being less than 10,000 mPa·s at 25° C. at a shear rate of between 100 s−1 and 100,000 s−1, wherein an emulsion (E2) is obtainedb) applying shear to the emulsion (E2), the applied shear rate being less than 1000 s−1, wherein an emulsion (E3) is obtained; andc) the polymerization of the composition C′2.